Metastatic differentiated thyroid cancer with undetectable serum thyroglobulin: diagnostic, management and follow-up challenges
نویسندگان
چکیده
منابع مشابه
The follow-up of patients with differentiated thyroid cancer and undetectable thyroglobulin (Tg) and Tg antibodies during ablation.
OBJECTIVE This retrospective study describes the role of serum thyroglobulin (Tg) in relation to tumor characteristics in the prediction of persistent/recurrent disease in patients with differentiated thyroid cancer (DTC) with negative Tg at the time of ablation. DESIGN Between 1989 and 2006, 94 out of 346 (27%) patients with DTC had undetectable Tg at the time of 131I ablation and were inclu...
متن کاملSerum thyroglobulin determination in the follow-up of patients with differentiated thyroid carcinoma.
Thyroglobulin (Tg) is produced only by thyroid follicular cells. Following total thyroid ablation, it should be undetectable in serum and any detectable level then indicates the persistence or recurrence of neoplastic disease. This is the basis for the use of Tg as a postoperative tumor marker in the follow-up of thyroid cancer patients (1). The aim of follow-up is the early detection of persis...
متن کاملSerum thyroglobulin concentrations and whole-body radioiodine scan in follow-up of differentiated thyroid cancer after thyroid ablation.
Measurement of serum thyroglobulin (Tg) concentrations and whole-body radioiodine scan were performed simultaneously during follow-up of 32 patients with differentiated thyroid cancer who had undergone thyroid ablation by operation and radioiodine. Almost all patients in whom serum Tg was undetectable had normal scans. Concentrations exceeding 50 ng/ml were invariably associated with residual o...
متن کاملSerum thyroglobulin and thyroid cancer.
Thyroglobulin is a large glycosylated protein (MW 660000 daltons) which is synthesised and secreted by the thyroid cell into the follicular lumen. In the thyroglobulin molecule the iodotyrosines undergo oxidative coupling to form the iodothyronines thyroxine (T4) and triiodothyronine (T3). Production of thyroid hormones results from micropinocytosis of iodinated thyroglobulin from the colloid i...
متن کاملSerum Thyroglobulin Measurement by Mass Spectrometry in the Follow-Up of Thyroid Cancer Patients
6 Asymptomatic Paget’s Disease — To Treat or Not to Treat Throughout most of the 20th century, thyroid carcinoma was considered a rare cancer with a low death rate. During the last 20 to 25 years, however, incidence rates of thyroid cancer have risen exponentially across the world. In combination with the low cause-specific mortality rate of thyroid cancer, this increase has led to huge numbers...
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ژورنال
عنوان ژورنال: Endocrine Abstracts
سال: 2015
ISSN: 1479-6848
DOI: 10.1530/endoabs.38.p479